Venous thromboembolic prophylaxis: the use of aspirin. Cham MD, Yankelevitz DF, Shaham D, et al. Burke DT. DVT has an annual incidence of about 1–2 per 1000 people. [Medline]. A blood clot in your legs can also happen if you don't move for a long time, such as after you have surgery or an accident, when you're traveling a long distance, or when you're on bed rest. 2000 Jul. Arch Intern Med. [Medline]. CLOTS (Clots in Legs Or sTockings after Stroke) Trials Collaboration. 1999. Ann Intern Med. Acharya G, Singh K, Hansen JB, Kumar S, Maltau JM. [Medline]. 2004 Feb. 43 (2):209-14. [Medline]. 2016 Jan. 279 (1):16-29. A comparative double-blind, randomised trial of a new second generation LMWH (bemiparin) and UFH in the prevention of post-operative venous thromboembolism. Arch Intern Med. [Medline]. 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The high-probability perfusion lung scan shows segmental perfusion defects in the right upper lobe and subsegmental perfusion defects in right lower lobe, left upper lobe, and left lower lobe. Image courtesy of Very Special Images with permission from Dr Lennard A Nadalo. 1999 Oct. 7(6):586-90. Araki CT, Back TL, Padberg FT, et al. [Medline]. 25 Suppl 3:83-9. [Medline]. Colwell C, Mouret P. Ximelagatran for the prevention of venous thromboembolism following elective hip or knee replacement surgery. Curr Cardiol Rep. 2014 Mar. For patients receiving maintenance VKA therapy for VTE, point-of-care INR testing by the patient at home with self-adjustment of VKA dose (PSM) is suggested in preference to any other management approach, including PST in suitable patients (those who have demonstrated competency to perform PSM and who can afford this option). US FDA approves Eliquis (apixaban) to reduce the risk of blood clots following hip or knee replacement surgery [press release]. Chang R, Chen CC, Kam A, Mao E, Shawker TH, Horne MK 3rd. Kearon C. Epidemiology of venous thromboembolism. [Medline]. Chu C, Tokumaru S, Izumi K, Nakagawa K. Obesity increases risk of anticoagulation reversal failure with prothrombin complex concentrate in those with intracranial hemorrhage. If you can't do that, exercise your lower legs. [Medline]. Who, when, and how to reverse non-vitamin K oral anticoagulants. Results of meta-analysis. Korelitz BI, Sommers SC. [Medline]. 1990 Oct. 4(5):483-9. The following are key points to remember from this joint consensus document from the European Society of Cardiology about the diagnosis and management of acute deep vein thrombosis (DVT): Clinical signs and symptoms of DVT are highly variable and nonspecific, but remain the cornerstone of diagnostic strategy. High with first use of the lower limb, with a spinning self-contained propeller that macerates clot. 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